Rhodium‐Catalyzed CH Alkynylation of Arenes at Room Temperature |
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| Authors: | Chao Feng Prof?Dr Teck‐Peng Loh |
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| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore);2. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China) |
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| Abstract: | The rhodium(III)‐catalyzed ortho C? H alkynylation of non‐electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. |
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| Keywords: | alkynes C H activation cross‐coupling iodine rhodium |
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