Palladium‐Catalyzed CS Activation/Aryne Insertion/Coupling Sequence: Synthesis of Functionalized 2‐Quinolinones |
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| Authors: | Ying Dong Bangyu Liu Peng Chen Prof Qun Liu Prof Mang Wang |
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| Institution: | Department of Chemistry, Northeast Normal University, Renmin Street 5268, 130024 Changchun (P. R. China) |
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| Abstract: | The insertion of an aryne into a C? S bond can suppress the addition of an S nucleophile to the aryne in the presence of palladium. Catalyzed by Pd(OAc)2, a wide range of α‐carbamoyl ketene dithioacetals readily react with arynes to selectively afford functionalized 2‐quinolinones in high yields under neutral reaction conditions by a C? S activation/aryne insertion/intramolecular coupling sequence. The attractive feature of the new strategy also lies in the versatile transformations of the alkythio‐substituted quinolinone products. |
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| Keywords: | annulation arynes C S activation heterocycles synthetic methods |
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