Zinc‐Catalyzed Borylation of Primary,Secondary and Tertiary Alkyl Halides with Alkoxy Diboron Reagents at Room Temperature |
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| Authors: | Dr Shubhankar Kumar Bose Dr Katharina Fucke Prof?Dr Lei Liu Prof?Dr Patrick G Steel Prof?Dr Todd B Marder |
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| Institution: | 1. Institut für Anorganische Chemie, Julius‐Maximilians‐Universit?t Würzburg, Am Hubland, 97074 Würzburg (Germany);2. Department of Chemistry, Tsinghua University, Beijing 100084 (China);3. Department of Chemistry, Durham University, South Road, Durham DH1 3LE (UK) |
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| Abstract: | A new catalytic system based on a ZnII NHC precursor has been developed for the cross‐coupling reaction of alkyl halides with diboron reagents, which represents a novel use of a Group XII catalyst for C? X borylation. This approach gives borylations of unactivated primary, secondary, and tertiary alkyl halides at room temperature to furnish alkyl boronates, with good functional‐group compatibility, under mild conditions. Preliminary mechanistic investigations demonstrated that this borylation reaction seems to involve one‐electron processes. |
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| Keywords: | boronate esters cross‐coupling homogeneous catalysis N‐heterocyclic carbenes Suzuki– Miyaura |
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