Manganese‐Catalyzed Hydrogen‐Autotransfer C−C Bond Formation: α‐Alkylation of Ketones with Primary Alcohols |
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| Authors: | Dr Miguel Peña‐López Patrick Piehl Saravanakumar Elangovan Dr Helfried Neumann Prof?Dr Matthias Beller |
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| Institution: | Leibniz-Institut für Katalyse e.V. an der Universit?t Rostock, Rostock, Germany |
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| Abstract: | A novel catalytic hydrogen‐autotransfer protocol for the atom‐efficient α‐alkylation of ketones with readily available alcohols is presented. The use of manganese complexes bearing non‐innocent PNP pincer ligands enabled the functionalization of a broad range of valuable ketones, including 2‐oxindole, estrone 3‐methyl ether, and testosterone. Mechanistic investigations suggest the participation of an intramolecular amidate‐assisted alcohol‐dehydrogenation process. |
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| Keywords: | alcohols atom economy hydrogen transfer ketones manganese catalysis |
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