Enantioselective Synthesis of Silacyclopentanes |
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| Authors: | Dr Kazunobu Igawa Daisuke Yoshihiro Yusuke Abe Prof?Dr Katsuhiko Tomooka |
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| Institution: | 1. Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan;2. Department of Molecular and Material Sciences, Kyushu University, Japan |
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| Abstract: | A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β‐eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β‐elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy‐functionalized silacyclopentane showed substantial binding to a serotonin receptor protein. |
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| Keywords: | asymmetric synthesis biological activity chirality elimination silicon |
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