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In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites |
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| Authors: | Prof?Dr Yi‐Xiang J Wang Dr Xiao‐Ming Zhu Qi Liang Prof?Dr Christopher H K Cheng Prof?Dr Wei Wang Prof?Dr Ken Cham‐Fai Leung |
| Institution: | 1. Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China);2. Department of Chemistry, Institute of Creativity, and State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR (P. R. China);3. Department of Radiology, Xianya Third Hospital, Central South University, Changsha, Hunan (P. R. China);4. School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (P. R. China) |
| Abstract: | A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent. |
| Keywords: | antitumor agents chemoembolization drug delivery iron oxide liver cancer |