Synthesis and Antimicrobial Activity of New 1,2,3‐Triazolopyrimidine Derivatives and Their Glycoside and Acyclic Nucleoside Analogs |
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| Authors: | Wael A El‐Sayed Omar M Ali Merfat S Faheem Ibrahim F Zied Adel A‐H Abdel‐Rahman |
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| Institution: | 1. Department of Photochemistry, National Research Centre, , Cairo, Egypt;2. Faculty of Science, Department of Chemistry, Menoufia University, , Shebin El‐Koam, Egypt |
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| Abstract: | New 1,2,4‐oxadiazolyl]methyl‐3H‐1,2,3]triazolo4,5‐d]pyrimidin derivatives were synthesized starting from N′‐Hydroxy‐1‐naphthimidamide. The N‐substituted acyclic nucleoside analogs as well as the substituted glycosides were also prepared by reaction with the corresponding reagents. The antimicrobial results indicated that most of the tested compounds exhibited moderate to high antimicrobial activity whereas few compounds were found to exhibit little or no activity against the tested microorganisms. |
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