AgI-promoted one-pot synthesis of aminoindolizines via sequential Mannich-Grignard addition and intramolecular cyclization in water |
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| Authors: | Veeranna Guguloth Ramesh Balaboina Suresh Paidakula Narasimha S Thirukovela Ravinder Vadde |
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| Institution: | 1. Department of Chemistry, Kakatiya University, Warangal, India;2. Department of Chemistry, Chaitanya (Deemed to be University), Warangal, India |
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| Abstract: | The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI-catalyzed one-pot three-component reaction of pyridine-2-carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich-Grignard addition as well as intramolecular cyclization was reported for the first time. |
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