An Efficient Synthesis of N‐Substituted‐3‐aryl‐3‐(4‐hydroxy‐6‐methyl‐2‐oxo‐2H‐pyran‐3‐yl)propanamides by Four‐Component Reaction in Aqueous Medium |
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| Authors: | Guo‐Lan Dou De‐Ming Wang Xiao‐Xing Zhong Da‐Qing Shi |
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| Institution: | 1. School of Safety Engineering, China University of Mining & Technology, , Xuzhou, 221116 China;2. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, , Suzhou, 215123 People's Republic of China |
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| Abstract: | A mild and efficient synthesis of N‐substituted‐3‐aryl‐3‐(4‐hydroxy‐6‐methyl‐2‐oxo‐2H‐pyran‐3‐yl)propanamides via four‐component reaction of an aldehyde, amine, Meldrum's acid, and 4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one in the presence of benzyltriethylammonium chloride (TEBAC) in aqueous medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions, and begin environmentally friendly. |
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