Synthesis and Characterization of Bis‐quinazolines from Linear Tetra‐amines Involving 2‐(Aminomethyl)benzenamine with Aldehydes |
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| Authors: | Reza Azadbakht Maryame Khodabandeh Hassan Keypour Reza Haji Hosseini Baghdad Abadi Hadi Amiri Rudbari |
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| Institution: | 1. Department of Chemistry, Payame Noor University (PNU), , Iran;2. Faculty of Chemistry, Bu Ali Sina university, , Hamedan, Iran;3. Dipartimento di Chimica Inorganica, Universitá di Messina, , Italy |
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| Abstract: | Three tetra‐amine compounds 2‐((2‐(2‐aminobenzylamino)ethylamino)methyl)benzenamine ( L1 ), 2‐((3‐(2‐aminobenzylamino)propylamino)methyl)benzenamine ( L2 ), and 2‐((4‐(2‐aminobenzylamino)butylamino)methyl)benzenamine ( L3 ) were synthesized and then their reaction with 2‐hydroxybenzaldehyde, 2‐nitrobenzaldehyde, and 2‐hydroxy‐3‐methoxybenzaldehyde were investigated. Treatment of L1 , L2 , and L3 with the former aldehydes gave derivatives of quinazolines in a good yield. The products have been studied with IR, 1H NMR, 13C NMR, COSY, HMQC, and microanalysis. |
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