Synthesis,Characterization, and Antimicrobial Studies of Novel Benzodipyran Analog of Chloramphenicol |
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Authors: | Rajesh G Kalkhambkar Geeta M Kulkarni Jagannath C Kadakol G Aridoss Yeon Tae Jeong Manohar V Kulkarni |
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Institution: | 1. Department of Chemistry, Karnatak Science College, , Dharwad, Karnataka, India;2. Department of Image Science and Engineering, Pukyong National University, , Busan, Republic of Korea;3. Postgraduate Department of Chemistry, Karnatak University Dharwad, , Karnataka, India |
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Abstract: | A synthesis, characterization, and antimicrobial study of a novel benzodipyran analog of chloramphenicol was carried out. Structure–antimicrobial activity relationship study indicates that benzodipyran analog of chloramphenicol was most active against Gram‐positive bacteria, Staphylococcus aureus, and the fungal strains Rhizoctonia bataticola and Penicillium even at minimum inhibitory concentration 10 µg/mL and showed moderate activity in other bacterial and fungal organisms. All the compounds synthesized during the present investigation were characterized by IR, 1H NMR, 13C NMR, ESI‐MS, and elemental analysis. |
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