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A new route to 2-amino- or 2-hydroxy-3-pyridinecarboxylic acid derivatives |
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| Authors: | Kunio Ito Seiichi Yokokura Shingo Miyajima |
| Abstract: | Schiff's bases derived from ketones and t-butylamine ( 1 ) reacted with methyl methoxymethylenemalonate to give 2-hydroxy-3-pyridinecarboxylates. Similarly, treatment of 1 with ethoxymethylenemalononitrile gave 2-amino-3-pyridinecarbonitriles. Compounds 1 on reaction with ethyl 2-cyano-3-ethoxypropenoate afforded 2-amino-3-pyridinecarboxylates. |
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