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Preparation of novel azidopyrazole derivatives with anticipated cytotoxic and antimicrobial activities |
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| Authors: | Ewies F Ewies Marwa El-Hussieny Naglaa F El-Sayed Mohamed El-Shazly Yu-Cheng Chen Yi-Chang Liu |
| Institution: | 1. Organometallic and Organometalloid Chemistry Department, National Research Centre, Giza, Egypt;2. Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt;3. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan;4. Divisions of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan |
| Abstract: | The reactions of azidopyrazole with some of primary amines and active methylene compounds were studied. Structures of the prepared compounds were identified using spectroscopic techniques. The reactions mechanisms were also proposed. The cytotoxic and antimicrobial activities were also examined for the newly synthesized compounds. |
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