Three-component reaction for synthesis of 2-amino-6-aryl-5-(phenylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one derivatives in water |
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| Authors: | Xiaopeng Yang Chunmei Li Chenze Qi Furen Zhang |
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| Institution: | School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, China |
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| Abstract: | A new three-component domino reaction for the synthesis of 2-amino-6-aryl-5-(phenylamino)-3,7-dihydro-4H-pyrrolo2,3-d]pyrimidin-4-one derivatives 4 using acetic acid as catalyst has been established. The reaction was performed in aqueous media using readily available and inexpensive 2,6-diaminopyrimidin-4(3H)-one 1 , 2,2-dihydroxy-1-arylethan-1-one 2 and aniline 3 as substrates. The simple and efficient one-pot three-component approach, inexpensive catalyst, green reaction media, make the present methodology a good synthetic procedure. |
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