Microwave‐Assisted Synthesis of Novel Bis(thiazoles) Incorporating Piperazine Moiety

Novel bis(hydrazinecarbothioamide) was prepared by the reaction of 1,4‐bis(3‐formyl‐4‐hydroxyphenyl)methyl]piperazine with thiosemicarbazide. The bis(hydrazinecarbothioamide) was used as a building block for construction of a novel bis(thiazolyl)piperazines via its cyclocondensation with a series of each of α‐halocarbonyl compounds and hydrazonoyl halides in dimethylformamide in the presence of triethylamine as a catalyst under microwave irradiation. The structure of the newly bis(thiazolyl)piperazine derivatives is elucidated via the spectral data as well as elemental analyses.