Synthesis of α‐Benzylthiobenzimidazoleacetonitriles and Their Chemoselective Reduction of the Double Bond with NaBH4 |
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Authors: | Srinivas Rao Sadhu Chittireddy Venkata Ramana Reddy Pramod Kumar Dubey |
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Institution: | Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Hyderabad, India |
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Abstract: | Condensation of 2‐((1H‐benzimidazol‐2‐yl)thio)acetonitre 1 with aromatic aldehydes in methanol containing piperidine gave the corresponding 2‐((1H‐benzimidazol‐2‐yl)thio)‐3‐arylacrylonitrile 2 , which on treatment with NaBH4 in ethanol unexpectedly and chemoselectively gave 2‐((1H‐benzimidazol‐2‐yl)thio)‐3‐arylpropanenitrile 3 by the reduction of the double bond of 2 . 3 on methylation with dimethyl sulfate containing K2CO3 as a base and tetrabutylammonium bromide as PTC gave 2‐((1‐methylbenzimidazol‐2‐yl)thio)‐3‐arylpropanenitrile 6 . The latter could also be prepared in an alternative way by reaction of 1 with dimethyl sulfate giving the intermediary 2‐((1‐methylbenzimidazol‐2‐yl)thio)acetonitrile 4 , followed by condensation with aromatic aldehydes yielding 5 and subsequent reduction of 5 with NaBH4 in methanol. 6 could be directly synthesized by treatment of 4 with benzyl chloride in DMF and triethylamine as a base at 60°C for 5 h. |
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