Regioselective Synthesis of Polyaza Pyrimidines and Polyaza Pyrazoles under One‐Pot Multicomponent Reaction Conditions |
| |
| Authors: | Okram Mukherjee Singh Laishram Ronibala Devi Ki Bum Lim Sang‐Gyeong Lee |
| |
| Institution: | 1. Department of Chemistry, Manipur University, Canchipur, Manipur, India;2. Department of Chemistry and Research Institute of Natural Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University, Jinju, Korea |
| |
| Abstract: | Convenient methods of synthesis of novel polyaza pyrimidines and polyaza pyrazoles have been described in this paper. The synthetic method is based on one‐pot, three‐component cyclocondensation of α‐oxoketene dithioacetals, 2,6‐diaminopyridine, and guanidine/hydrazine. Polyaza S,N‐acetals have been generated in situ by treating α‐oxoketene dithioacetals with 2,6‐diaminopyridine in the presence of n‐butyl lithium, which were subsequently treated with guanidine nitrate and hydrazine hydrate to afford polyaza pyrimidines and polyaza pyrazoles, respectively. |
| |
| Keywords: | |
|
|
