Modelling of icosahedral viruses |
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| Institution: | 1. Department of Chemistry and the Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS, United States;2. Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., Kenilworth, NJ, USA;1. College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, P. R. China;2. Liaoning Province Professional and Technical Innovation Center for Fine Chemical Engineering of Aromatics Downstream, School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang, 111003, Liaoning, P. R. China |
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| Abstract: | Theoretical and simulation investigations of viruses attaining icosahedral shape based on molecular models have recently become an exciting and rapidly growing research area. We discuss recent studies addressing the packing of the genome inside the capsid, thermodynamics, and the self-assembly of capsids. Special attention is given to the different packing of double-stranded and single-stranded polynucleotides in the viral capsid and its consequences. |
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