DNA adsorbed on graphene and graphene oxide: Fundamental interactions,desorption and applications |
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| Institution: | 1. Fusion and Nuclear Security Department, ENEA, Via E. Fermi 45, 00044 Frascati, Italy;2. Department of Astronautic, Electrical and Energy Engineering, Sapienza University of Rome, Via Salaria 851-881, 00138 Rome, Italy;3. Horiba Italia s.r.l, Viale L. Gaurico 209, 00143 Rome, Italy;4. Department of Micro & Nanotechnology, Technical University of Denmark, Lyngby 2800, Denmark;5. Department of Chemical Materials and Environmental Engineering, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy;1. Shandong Provincial Key Laboratory of Biophysics, College of Physics and Electronic Information, Dezhou University, Dezhou 253023, China;2. School of Physics and Electronics, Shandong Normal University, Jinan 250014, China;1. Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Republic of Korea;2. Polytechnic School, Universidade do Vale do Rio dos Sinos, São Leopoldo, 93022-750, Brazil;1. Laboratory of Quality & Safety Risk Assessment for Citrus Products (Chongqing), Ministry of Agriculture, Citrus Research Institute, Southwest University, Chongqing 400712, China;2. National Citrus Engineering Research Center, Chongqing 400712, China |
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| Abstract: | Interfacing DNA oligonucleotides with graphene-based materials, especially graphene oxide, has produced many new sensors and devices. Since graphene oxide is an excellent fluorescence quencher, fluorescently labeled DNAs (probes) are nearly fully quenched upon adsorption. Addition of the complementary DNA results in probe desorption and fluorescence enhancement. Aside from its analytical applications, this system provides a fascinating topic for biointerface science. DNA can be adsorbed by graphene oxide via π–π stacking and hydrogen bonding, while it must overcome electrostatic repulsion at the same time. The mechanism of DNA-induced probe desorption has also been a topic of extensive discussion. In this article, DNA adsorption and desorption reactions and interactions with graphene oxide and related materials (e.g. graphene) are reviewed based on the current understandings. A few representative applications based on these processes are also described briefly. |
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