Self-emulsification in chemical and pharmaceutical technologies |
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Institution: | 1. Department of Chemical and Pharmaceutical Engineering Faculty of Chemistry and Pharmacy,University of Sofia, 1 James Bourchier Ave., 1164 Sofia, Bulgaria;2. Unilever R & D, Colworth, UK |
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Abstract: | The interest in the low energy self-emulsification techniques has exploded in the recent years, driven by three main trends: by the transition to “greener” technologies in both its aspects—less energy consumption and replacement of the petrochemicals by natural ingredients; by the costly and maintenance demanding equipment for nanoemulsification; and by the quest for efficient and robust self-emulsifying formulations for oral drug delivery. Here, we first present a brief overview of the main known low-energy methods for nanoemulsion formation, focusing on their mechanistic understanding and discussing some recent advances in their development and applications. Next, we review three conceptually new approaches for self-emulsification in chemical technologies, discovered in the last several years. The colloidal features and the specific requirements of the self-emulsifying drug-delivery systems (SEDDS) are also discussed briefly. Finally, we summarize the current trends and the main challenges in this vivid research area. |
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Keywords: | Nanoemulsion Self-emulsification Phase inversion Cold-bursting SEDDS |
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