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A miniaturized solid-contact potentiometric multisensor platform for determination of ionic profiles in human saliva |
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| Authors: | Urbanowicz Marcin Pijanowska Dorota G Jasiński Artur Ekman Marcin Bocheńska Maria K |
| Institution: | 1.Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Ks. Trojdena 4, 02-109, Warsaw, Poland ;2.Department of Chemistry and Technology of Functional Materials, Chemical Faculty, Gdańsk University of Technology, Narutowicza 11/12, 80-233, Gdańsk, Poland ;3.Department of Surgical Oncology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214, Gdańsk, Poland ; |
| Abstract: | This paper describes a miniaturized multisensor platform (MP-ISES) consisting of electrodes: a reference one (RE) and ion-selective electrodes (ISEs) for monitoring Na+, K+, Ca2+, Mg2+, Cl−, and SCN− ions and pH in human saliva. Gold electrode surface was modified by deposition of two layers: electrosynthesized PEDOT:PSS forming an intermediate layer, and ion-selective membrane. The developed ISEs were characterized by a wide linear range and sensitivity consistent with the Nernst model. The entire MP-ISEs are characterized by satisfactory metrological parameters demonstrating their applicability in biomedical research, in particular in measurements concerning determination of ionic profiles of saliva. Saliva samples of 18 volunteers aged from 20 to 26 participating in a month experiment had been daily collected and investigated using the MP-ISEs assigned individually to each person. Personalized profiles of ions (ionograms) in saliva, such as Na+, K+, Ca2+, Mg2+, Cl−, SCN−, and H+, were obtained. |
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