Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid |
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Authors: | Rolff Ferreira Spindola Hudson Zanin Cleidivan Silva Macena André Contin Rita de Cássia Silva Luz Flávio Santos Damos |
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Institution: | 1.Laboratory of Sensors, Devices and Analytical Methods, Department of Chemistry,Federal University of Maranh?o,S?o Luís,Brazil;2.Carbon Sci-Tech Labs, School of Electrical and Computer Engineering,University of Campinas,Campinas,Brazil;3.National Institute of Space Research,S?o José dos Campos,Brazil |
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Abstract: | A novel platform for electroanalysis of isoniazid based on graphene-functionalized multi-walled carbon nanotube as support for iron phthalocyanine (FePc/f-MWCNT) has been developed. The FePc/f-MWCNT composite has been dropped on glassy carbon forming FePc/f-MWCNT/GC electrode, which is sensible for isoniazid, decreasing substantially its oxidation potential to +200 mV vs Ag/AgCl. Electrochemical and electroanalytical properties of the FePc/f-MWCNT/GC-modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, and amperometry. The sensor presents better performance in 0.1 mol L?1 phosphate buffer at pH 7.4. Under optimized conditions, a linear response range from 5 to 476 μmol L?1 was obtained with a limit of detection and sensitivity of 0.56 μmol L?1 and 0.023 μA L μmol?1, respectively. The relative standard deviation for 10 determinations of 100 μmol L?1 isoniazid was 2.5%. The sensor was successfully applied for isoniazid selective determination in simulated body fluids. |
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