A highly enantio- and diastereoselective molybdenum-catalyzed asymmetric allylic alkylation of cyanoesters |
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| Authors: | Trost Barry M Miller John R Hoffman Christopher M |
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| Institution: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu |
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| Abstract: | An efficient molybdenum-catalyzed asymmetric allylic alkylation (Mo-AAA) of cyanoester nucleophiles is reported. A number of highly functionalized branched cyanoesters containing a quaternary carbon stereocenter with a vicinal tertiary stereocenter are obtained. This method generates a number of functionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivity and enantioselectivity. |
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