Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes |
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| Authors: | Gasparac Rahela Taft Bradford J Lapierre-Devlin Melissa A Lazareck Adam D Xu Jimmy M Kelley Shana O |
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| Institution: | Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA. |
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| Abstract: | Electrochemical DNA detection systems are an attractive approach to the development of multiplexed, high-throughput DNA analysis systems for clinical and research applications. We have engineered a new class of nanoelectrode ensembles (NEEs) that constitute a useful platform for biomolecular electrochemical sensing. High-sensitivity DNA detection was achieved at oligonucleotide-functionalized NEEs using a label-free electrocatalytic assay. Attomole levels of DNA were detected using the NEEs, validating the promise of nanoarchitectures for ultrasensitive biosensing. |
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