Deep-UV surface-enhanced resonance Raman scattering of adenine on aluminum nanoparticle arrays |
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Authors: | Jha Shankar K Ahmed Zeeshan Agio Mario Ekinci Yasin Löffler Jörg F |
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Institution: | Laboratory of Metal Physics and Technology, Department of Materials, ETH Zürich, 8093 Zürich, Switzerland. shankar.jha@mat.ethz.ch |
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Abstract: | We report the ultrasensitive detection of adenine using deep-UV surface-enhanced resonance Raman scattering on aluminum nanostructures. Well-defined Al nanoparticle arrays fabricated over large areas using extreme-UV interference lithography exhibited sharp and tunable plasmon resonances in the UV and deep-UV wavelength ranges. Theoretical modeling based on the finite-difference time-domain method was used to understand the near-field and far-field optical properties of the nanoparticle arrays. Raman measurements were performed on adenine molecules coated uniformly on the Al nanoparticle arrays at a laser excitation wavelength of 257.2 nm. With this technique, less than 10 amol of label-free adenine molecules could be detected reproducibly in real time. Zeptomole (~30,000 molecules) detection sensitivity was readily achieved proving that deep-UV surface-enhanced resonance Raman scattering is an extremely sensitive tool for the detection of biomolecules. |
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