Inert site in a protein zinc cluster: isotope exchange by high resolution mass spectrometry |
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| Authors: | Blindauer Claudia A Polfer Nick C Keiper Stella E Harrison Mark D Robinson Nigel J Langridge-Smith Pat R R Sadler Peter J |
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| Institution: | School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, U.K. |
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| Abstract: | Using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, we show that one Zn2+ ion in the Zn4 cluster of cyanobacterial metallothionein is inert to exchange with 67Zn2+. We suggest that this is zinc in site A, which together with the surrounding alpha and beta secondary structure forms a zinc-finger fold. |
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