Novel fluorophores for single-molecule imaging |
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Authors: | Willets Katherine A Ostroverkhova Oksana He Meng Twieg Robert J Moerner W E |
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Institution: | Department of Chemistry, Stanford University, Stanford, California 94305, USA. |
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Abstract: | Nonlinear optical chromophores based on dicyanodihydrofuran acceptors paired with amine donors have been found to exhibit sufficiently large fluorescence quantum yields and stability to enable single-molecule detection in polymeric hosts. To illustrate the breadth of this class, six fluorophores are presented, spanning the emission range from 505 to 646 nm. In contrast to conventional single-molecule fluorophores, the new molecules feature sensitivity to local rigidity, large ground-state dipole moments, and large polarizability anisotropies, properties that can be used to design new reporter experiments at the single-molecule level. |
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