Design and synthesis of biotin chain-terminated glycopolymers for surface glycoengineering |
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| Authors: | Sun Xue-Long Faucher Keith M Houston Michelle Grande Daniel Chaikof Elliot L |
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| Institution: | Laboratory for Biomolecular Materials Research, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA. xsun@emory.edu |
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| Abstract: | Biotin chain-terminated glycopolymers were generated by cyanoxyl-mediated free-radical polymerization using a biotin-derivatized arylamine initiator with high conversion (75%) and low polydispersity (1.30). Streptavidin-biotinylated glycopolymer binding was verified by SDS-PAGE gel shift assay and patterned glycocalyx-mimetic surfaces successfully fabricated. |
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