Synthesis and Characterization of Chloralose-Derived Thiosemicarbazones and Semicarbazones and Investigation of Their Antimicrobial Properties |
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Authors: | Can Emre Yetgin Mustafa Oskay |
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Institution: | 1. Department of Chemistry, Faculty of Arts and Sciences, Celal Bayar University, Campus of Muradiye, 45030, Manisa, Turkey;2. Department of Biology, Faculty of Arts and Sciences, Celal Bayar University, Campus of Muradiye, 45030, Manisa, Turkey |
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Abstract: | Thiosemicarbazones(7–10)/semicarbazones(11–14) were synthesized in good yields via the condensation of α-gluco-, β-gluco-, galacto-, manno- chloralose derived 1,4-furanodialdoses (1-4) with thiosemicarbazide(5)/semicarbazide(6). The structures of all products were characterized by FTIR, NMR spectroscopic methods and elemental analysis. The compounds have been found to display moderate antimicrobial activity against Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. MIC values of the compounds range from 260 to 1510 μg/mL. |
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Keywords: | Thiosemicarbazone Semicarbazone Chloralose Antimicrobial activity |
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