Absorption and fluorescence spectral studies of the interaction of sulpha drugs with α-cyclodextrin |
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Authors: | Amalendu Pal Surbhi Soni |
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Institution: | Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India |
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Abstract: | The spectral characteristics of different drugs i.e. sulfanilamide, sulfanilic acid, sulfosalicylic acid dihydrate (SSAD) and sulfamethoxazole in aqueous α-cyclodextrin (CD) have been investigated at neutral pH. The formation of inclusion complexes of sulfa drugs with α-CD leads to the changes in fluorescence and absorption spectra which further enable the calculation of association constant of the bind processes by implementing the non-linear regression on the experimental data. The standard Gibbs energy ΔG was also calculated for the systems in which complex formation was observed. The α-CD study indicates that the sulpha drugs form 1:1 inclusion complex with α-CD. |
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Keywords: | Absorption fluorescence sulpha drugs cyclodextrin |
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