Sonogashira cross-couplings of ynamides. Syntheses of urethane- and sulfonamide-terminated conjugated phenylacetylenic systems |
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| Authors: | Tracey Michael R Zhang Yanshi Frederick Michael O Mulder Jason A Hsung Richard P |
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| Institution: | Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. |
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| Abstract: | reaction: see text] The first successful Sonogashira coupling of ynamides with aryl and vinyl iodides is described here. This study resolves the problem of the competing pathway involving homocoupling of ynamides and provides a practical entry to novel urethane- or sulfonamide-terminated conjugated acetylenic systems. An interesting tandem hydrohalogenation and Sonogashira coupling was also observed to give an en-ynamide. |
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