Enzymatic reductions for the regio- and stereoselective synthesis of hydroxy-keto esters and dihydroxy esters |
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Authors: | Bariotaki Anna Kalaitzakis Dimitris Smonou Ioulia |
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Institution: | Department of Chemistry, University of Crete, Heraklion 71003, Crete, Greece. |
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Abstract: | Ketoreductases were utilized for the stereoselective synthesis of δ-hydroxy-β-keto esters, β-hydroxy-δ-keto esters, and β,δ-dihydroxy esters. Seven out of eight possible stereoisomers were obtained from the enzymatic reduction of the corresponding β,δ-diketo ester in high enantio- and diastereomeric excess. |
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