Electrochemical carboxylation of N-(2-bromopropionyl)-4R- phenyloxazolidin-2-one: an efficient route to unsymmetrical methylmalonic ester derivatives |
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| Authors: | Feroci Marta Inesi Achille Orsini Monica Palombi Laura |
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| Institution: | Dipartimento di Ingegneria Chimica, Materiali, Materie Prime e Metallurgia, Università La Sapienza, via Castro Laurenziano, 7, I-00161 Roma, Italy. marta.feroci@uniroma1.it |
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| Abstract: | reaction: see text] Electrochemical carboxylation of N-(2-bromopropionyl)-4R-phenyloxazolidin-2-one aimed at the synthesis and chiral resolution of unsymmetrical methylmalonic ester derivatives is described. The presence of the Evans' chiral auxiliary permits an easy resolution of the mixture of the two diastereoisomers. |
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