Synthesis of novel D-2'-deoxy-2'-C-difluoromethylene-4'-thiocytidine as a potential antitumor agent |
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| Authors: | Lim Moo Hong Kim Hea Ok Moon Hyung Ryong Chun Moon Woo Jeong Lak Shin |
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| Institution: | College of Pharmacy and Division of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea. |
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| Abstract: | reaction: see text] 2'-Deoxy-2'-C-difluoromethylene-4'-thiocytidine (4) as a potential antitumor agent was synthesized starting from L-xylose via 2-deoxy-2-C-difluoromethylene-4-thiosugar as a key intermediate. An elimination product, 8, was always formed as the major product during removal of the protecting groups under acidic or basic conditions. However, utilizing neutral reaction conditions to remove the protecting groups afforded the desired product 4 exclusively. |
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