Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer |
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| Authors: | Guarracino Danielle A Chiang Hyojin R Banks Tereece N Lear James D Hodsdon Michael E Schepartz Alanna |
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| Institution: | Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA. |
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| Abstract: | STRUCTURE: SEE TEXT] We report a systematic analysis of the relationship between salt bridge composition and 14-helix structure within a family of model beta-peptides in aqueous buffer. We find an inverse relationship between side-chain length and the extent of 14-helix structure as judged by CD. Introduction of a stabilizing salt bridge pair within a previously reported beta-peptide ligand for hDM2 led to changes in structure that were detectable by NMR. |
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