An enantioselective total synthesis of (+)-aigialospirol |
| |
Authors: | Figueroa Ruth Hsung Richard P Guevarra Christle C |
| |
Institution: | Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA. |
| |
Abstract: | A concise and enantioselective total synthesis of (+)-aigialospirol is described here, featuring the first complex natural product synthesis that employs a cyclic ketal-tethered ring-closing metathesis strategy and an unexpected stereoselective epimerization of a benzylic hydroxyl group. The 15-step synthetic sequence illustrates the proof-of-concept that such an approach can be competitive with the classical spiroketal formation in the natural product synthesis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|