Total synthesis of (+)-epiquinamide |
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Authors: | Wijdeven Marloes A Botman Peter N M Wijtmans Roel Schoemaker Hans E Rutjes Floris P J T Blaauw Richard H |
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Institution: | Chiralix B.V., P.O. Box 31070, 6503 CB Nijmegen, The Netherlands, Radboud University Nijmegen, IMM, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands. |
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Abstract: | The stereoselective total synthesis of the novel quinolizidine alkaloid (+)-epiquinamide is presented, starting from the amino acid l-allysine ethylene acetal. Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylation and a ring-closing metathesis reaction to provide the bicyclic skeleton. reaction: see text] |
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