A novel three-component one-pot pyrimidine synthesis based upon a coupling-isomerization sequence |
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Authors: | Müller T J Braun R Ansorge M |
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Institution: | Department Chemie, Ludwig-Maximilians-Universit?t München, Butenandtstr. 5-13 (Haus F), D-81377 München, Germany. |
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Abstract: | reaction: see text] 2,4,6-Tri(hetero)aryl-substituted pyrimidines can be readily synthesized in a three-component one-pot process based upon a coupling-isomerization sequence of an electron-poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with amidinium salts. |
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