Plastic membrane electrodes responsive to beta-blocker drugs |
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| Authors: | Zhang Z R Yi Mao D Li Y X Coşofreţ V V |
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| Institution: | Department of Chemistry, Shanghai Teacher's University, 10 Guilin Road, Shanghai, People's Republic of China. |
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| Abstract: | The construction and performance characteristics of ion-selective PVC membrane electrodes for metoprolol, propranolol and timolol are described. The electrodes, based on ion-pair complexes with dinonylnaphthalenesulphonate or with tetra(2-chlorophenyl)borate show near-Nernstian responses down to 10(-5)M drug concentration. Their selectivity relative to various inorganic and organic cations is reported. Direct potentiometry is used to determine beta-blocker drugs both in aqueous solutions and pharmaceutical preparations, with good results. |
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