| PEG化的聚合物载体树脂研究进展 |
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| 引用本文： | 王征,杨汝磊,朱俊东,朱晓夏.PEG化的聚合物载体树脂研究进展[J].中国科学:化学,2010(8):991-1000. |
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| 作者姓名： | 王征 杨汝磊 朱俊东 朱晓夏 |
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| 作者单位： | [1]天津大学药物科学与技术学院,天津300072 [2]Département de chimie,Université de Montréal,Montréal,QC H3C 3J7,Canada |
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| 基金项目： | 国家自然科学基金（20674055）; 加拿大首席研究基金的资助 |
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| 摘 要： | 组合化学已成为发现和优化新药、亲和配体和催化过程中的重要组成部分.高分子载体树脂在组合化学中起着关键的作用,各种类型的聚合物树脂在有机合成中已被广泛开发为载体、反应物和催化剂.与传统的Merrifield树脂相比较,聚乙二醇(PEG)化的聚合物树脂具有与极性溶剂更好的相容性、更高的溶剂吸收和溶胀性能.本文主要综述与PEG相关联的聚合物树脂在有机合成载体领域中的最新成果.
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| 关 键 词： | 组合化学 聚合物载体树脂 聚乙二醇（PEG）化 有机合成 |
PEG-related polymer resins as synthetic supports |
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| WANG Zheng,YANG RuLei,ZHU JunDong,ZHU XiaoXia.PEG-related polymer resins as synthetic supports[J].Scientia Sinica Chimica,2010(8):991-1000. |
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| Authors: | WANG Zheng YANG RuLei ZHU JunDong ZHU XiaoXia |
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| Institution: | 1 School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China;2 Département de chimie,Université de Montréal,Montréal,QC H3C 3J7,Canada ) |
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| Abstract: | Combinatorial chemistry has become a significant part of the discovery and optimization process for novel drugs,affinity ligands,and catalysts. The polymeric supports play a key role in combinatory chemistry. Therefore,various kinds of functional polymer resins have been exploited as supports,reagents,and catalysts in organic synthesis. In comparison to the conventional Merrifield resins,the poly（ethylene glycol） （PEG）-related polymer resins have advantages including good compatibilities with polar solvents,good solvent absorbency and swelling properties. This review focuses primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis. |
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| Keywords: | combinatorial chemistry polymer resins poly（ethylene glycol） organic synthesis |
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