| 高通量药物筛选现代检测技术研究进展 |
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| 引用本文： | 郑枫,刘文英,吴峥.高通量药物筛选现代检测技术研究进展[J].中国科学:化学,2010(6):599-610. |
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| 作者姓名： | 郑枫 刘文英 吴峥 |
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| 作者单位： | 药品质量与安全预警教育部重点实验室 中国药科大学药物分析教研室,南京210009 |
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| 基金项目： | 国家自然科学基金（30901878）项目资助 |
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| 摘 要： | 高通量药物筛选是发现创新药物的重要技术途径.高通量筛选结果必须通过适当的检测方法才能反映出来,检测技术是实现高通量药物筛选的基础.本文综述了近年来有关光学分析、色谱分析、热分析、电化学分析、质谱、核磁共振等现代检测技术在高通量药物筛选研究中的进展.
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| 关 键 词： | 高通量药物筛选 现代检测技术 |
Development of modern detection technologyfor high-throughput screening |
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| ZHENG Feng,LIU WenYing ＆ WU Zheng.Development of modern detection technologyfor high-throughput screening[J].Scientia Sinica Chimica,2010(6):599-610. |
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| Authors: | ZHENG Feng LIU WenYing ＆ WU Zheng |
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| Institution: | Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education;Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | High-throughput screening（HTS） is an important strategy for drug discovery.Because high-throughput screening results may be presented only by suitable detection methods,detection technology for high-throughput screening is necessary for the realization of HTS.In this paper,the development of detection technology for high-throughput screening is summarized,including optical analysis,chromatographic analysis,thermal analysis,electrochemical analysis,mass spectrum analysis,NMR analysis,etc. |
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| Keywords: | high-throughput screening modern detection technology |
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