| 二苯基哌嗪磺胺化合物的合成及其抗微生物活性 |
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| 引用本文： | 王宪龙,甘淋玲,闫聪彦,周成合.二苯基哌嗪磺胺化合物的合成及其抗微生物活性[J].中国科学:化学,2011(3):451-460. |
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| 作者姓名： | 王宪龙 甘淋玲 闫聪彦 周成合 |
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| 作者单位： | 西南大学化学化工学院;西南大学药学院; |
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| 基金项目： | 西南大学人才引进基金(SWUB2006018),西南大学高新技术培育基金(XSGX0602); 重庆市自然科学基金(CSCT2009BB5296); 国家人事部回国人员重点项目(2002-99)资助 |
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| 摘 要： | 以乙酰苯胺和4-氯二苯甲酮为起始原料,经多步反应方便而有效地合成了二苯基哌嗪磺胺化合物,所得目标化合物及其中间体的结构经1H NMR、13C NMR、IR、MS谱和元素分析等证实.研究了化合物的体外抗微生物活性,结果表明目标化合物14和16对所测菌株的抗菌活性均优于磺胺.
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| 关 键 词： | 磺胺 哌嗪 三唑 抗微生物 抗菌 |
Synthesis and their evaluation for their antimicrobial activity of diphenyl piperazine-based sulfanilamides |
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| WANG XianLong,GAN LinLing,YAN CongYan & ZHOU ChengHe School of Chemistry , Chemical Engineering,Southwest University,Chongqing ,China School of Pharmaceutical Sciences,China.Synthesis and their evaluation for their antimicrobial activity of diphenyl piperazine-based sulfanilamides[J].Scientia Sinica Chimica,2011(3):451-460. |
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| Authors: | WANG XianLong GAN LinLing YAN CongYan & ZHOU ChengHe School of Chemistry Chemical Engineering Southwest University Chongqing China School of Pharmaceutical Sciences China |
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| Institution: | WANG XianLong1,GAN LinLing2,YAN CongYan1 & ZHOU ChengHe1 1 School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China 2 School of Pharmaceutical Sciences,China |
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| Abstract: | The novel diphenyl piperazine-based sulfanilamides were conveniently and efficiently synthesized via multi-step reactions starting from commercially available acetanilide and (4-chlorophenyl)(phenyl)methanone. The synthesized title compounds and their intermediates were characterized by 1H NMR, 13C NMR, IR and MS spectra as well as elemental analyses and screened in vitro for their antibacterial and antifungal activities. The antimicrobial activity showed that the target compounds 14 and 16 exhibited better... |
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| Keywords: | sulfanilamide piperazine triazole antimicrobial antibacterial |
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