稀土发挥生物效应的机制及其作用物种探讨

稀土在工业、医药领域、基础研究以及在我国的广泛农用引起了人们对其生物效应机理以及可能毒性的关注.在稀土生物学效应机理及毒性的研究中,无论是在动物水平还是细胞层次,引起生物学效应的稀土物种都是一个关键问题,一直存在争议.本文对以动物、细胞为模型的生物效应研究中的实验条件进行分析,对生理条件下引起稀土生物学效应的可能物种提出"稀土离子池"(rare earth ion pool)模型,并对其引起生物学效应的活性物种以及与细胞膜相互作用的方式进行了探讨,以期为阐明复杂生物学体系中稀土化合物的作用机制提供思路.

Chemical species and mechanisms underlying biological effects of rare earth elements

There are widespread applications of rare earth elements （REEs） for basic research, industrial, agricultural and medical purposes. These extensive applications inevitably raise deep concerns regarding the mechanisms underlying biological effects of REEs and their possible toxicities. The chemical species to exert the biological effects is certainly the key issue for the study in both the whole animal and the cellular level, which has always been a controversial topic. In the present review, we analyzed the expeimental conditions in the study and proposed a model termed as ＂rare earth ion pool＂ concerning the possible chemical species to exert the biological effects under the physiological conditions. The modes of action between the active entities of REEs and the cell membrane have been discussed. The working mechanisms for the REEs in the complicated biological system are indicated.