Stereoselectivity of (?)-(1<Emphasis Type="Italic">R</Emphasis>,2<Emphasis Type="Italic">S</Emphasis>)-2-methylamino-1-phenylpropan-1-ol preparation |
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Authors: | Martina Astrová Ladislav Kurc Libor ?ervený |
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Institution: | (1) Department of Organic Technology, Institute of Chemical Technology in Prague, Technická 5, 166 28 Praha 6, Czech Republic |
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Abstract: | Stereoselectivity of reductive amination of (R)-1-hydroxy-1-phenylpropan-2-one by methylamine was studied. From the four isomers possible, only two are produced by this
reaction. These are marked as (−)-(1R,2S)-ephedrine (desired product) and (+)-(1S,2R)-ephedrine. The reaction stereoselectivity depends both on the type of the catalyst and reaction conditions. The most suitable
type is the supported platinum. However, this catalyst rapidly deactivates. With a decreasing activity of Pt catalyst, the
stereoselectivity decreases. It is also decreased during the production of the second liquid phase (water) in the reaction
mixture. |
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Keywords: | Stereoselectivity ephedrine hydrogenation liquid phase |
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