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| 以3,4-二羟基肉桂酸为介质的多壁碳纳米管糊电极用于检测药物和尿液样品中的谷胱甘肽(英文) | |
| 作者姓名： | Mohsen Keyvanfard Hassan Karimi-Maleh Khadijeh Alizad |
| 作者单位： | a Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran; b Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran |
| 基金项目： | supported by Majlesi Branch,Islamic Azad University,Isfahan,Iran |
| 摘 要： | A sensitive and selective electrochemical sensor for the determination of glutathione(GSH) was developed using a modified multiwall carbon nanotube paste electrode with 3,4 dihydroxy cinnamic acid as a mediator.This modified electrode showed very high electrocatalytic activity for the anodic oxidation of GSH.Under the optimized conditions,the electrocatalytic peak current showed a linear relationship with GSH concentration in the range of 0.5-400.0 μmol/L with a detection limit of 0.1 μmol/L GSH.The relative standard deviations for seven successive assays of 5.0 and 25.0 μmol/L GSH were 2.2% and 2.7%,respectively.The modified electrode was used for the determination of GSH compounds in real urine samples. |
| 关 键 词： | Glutathione 3 4-Dihydroxy-cinnamic acid Carbon paste electrode Multiwall carbon nanotube Sensor |
| 收稿时间： | 2013-05-10 |
Multiwall carbon nanotube paste electrode with 3,4-dihydroxy-cinnamic acid as mediator for the determination of glutathione in pharmaceutical and urine samples |
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| Mohsen Keyvanfard,Hassan Karimi-Maleh,Khadijeh Alizad.Multiwall carbon nanotube paste electrode with 3,4-dihydroxy-cinnamic acid as mediator for the determination of glutathione in pharmaceutical and urine samples[J].Chinese Journal of Catalysis,2013,34(10):1883-1889. | |
| Authors: | Mohsen Keyvanfard Hassan Karimi-Maleh Khadijeh Alizad |
| Institution: | a Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran; b Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran |
| Abstract: | A sensitive and selective electrochemical sensor for the determination of glutathione (GSH) was developed using a modified multiwall carbon nanotube paste electrode with 3,4-dihydroxy-cinnamic acid as a mediator. This modified electrode showed very high electrocatalytic activity for the anodic oxidation of GSH. Under the optimized conditions, the electrocatalytic peak current showed a linear relationship with GSH concentration in the range of 0.5-400.0 μmol/L with a detection limit of 0.1 μmol/L GSH. The relative standard deviations for seven successive assays of 5.0 and 25.0 μmol/L GSH were 2.2% and 2.7%, respectively. The modified electrode was used for the determination of GSH compounds in real urine samples. |
| Keywords: | Glutathione 3 4-Dihydroxy-cinnamic acid Carbon paste electrode Multiwall carbon nanotube Sensor |
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