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| 一种新型双亲性有机小分子催化剂在水相体系中催化环己酮与硝基烯烃直接不对称Michael加成反应 | |
| 引用本文： | 魏建伟,郭文岗,张博宇,刘,杜欣,李灿.一种新型双亲性有机小分子催化剂在水相体系中催化环己酮与硝基烯烃直接不对称Michael加成反应[J].催化学报,2014,35(7):1008-1011. |
| 作者姓名： | 魏建伟 郭文岗 张博宇 刘 杜欣 李灿 |
| 作者单位： | a. 大连理工大学化工学院, 辽宁大连110624; b. 中国科学院大连化学物理研究所催化基础国家重点实验室, 辽宁大连110623 |
| 基金项目： | supported by the National Natural Science Foundation of China (21002100);the Fundamental Research Funds for the Central Universities of China (DUT12LK07)~~ |
| 摘 要： | 设计合成了一系列基于脯氨酸巯基咪唑衍生物的新型双亲性有机小分子催化剂，在水相中加入酸作为助催化剂，可以高效高选择性的催化环己酮与硝基烯烃的不对称Michael加成反应，非对映选择性和对映选择性分别高达99：1和96%. |
| 关 键 词： | 不对称催化 乳液 有机催化 迈克尔加成 |
| 收稿时间： | 2013-12-21 |
An amphiphilic organic catalyst for the direct asymmetric Michael addition of cycloketone to nitroolefins in water |
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| Jianwei Wei,Wengang Guo,Boyu Zhang,Yan Liu,Xin Du,Can Li.An amphiphilic organic catalyst for the direct asymmetric Michael addition of cycloketone to nitroolefins in water[J].Chinese Journal of Catalysis,2014,35(7):1008-1011. | |
| Authors: | Jianwei Wei Wengang Guo Boyu Zhang Yan Liu Xin Du Can Li |
| Institution: | a. Department of Chemistry, Dalian University of Technology, Dalian 116024, Liaoning, China; b. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China |
| Abstract: | A series of amphiphilic proline-derived mercapto imidazole organic catalysts were synthesized and shown to be very effective with an acid cocatalyst for the asymmetric Michael addition reaction of ketones to nitroolefins with high diastereoselectivity (up to 99:1) and execellent enantioselectivity (up to 96%) using water as solvent. |
| Keywords: | Asymmetric catalysis Emulsion Organocatalysis Michael addition |
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