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Cu(I)-catalyzed cascade reaction of N-tosylhydrazones with 3-butyn-1-ol: A new synthesis of tetrahydrofurans |
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| Authors: | Mohammad Lokman Hossain Kang Wang Fei Ye Yan Zhang Jianbo Wang |
| Institution: | 1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China |
| Abstract: | The Cu(I)-catalyzed cascade coupling/cyclization reaction of N-tosylhydrazones with 3-butyn-1-ol has been explored. This new strategy represents a simple platform for the synthesis of tetrahydrofurans in moderate to good yields. |
| Keywords: | Copper catalysis Allene Tetrahydrofuran Cross coupling Terminal alkynes |
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