Synthesis and in vitro antimicrobial studies of thiodihydropyrimidine derivatives |
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| Authors: | Mani Pasupathi Namasivayam Santhi Kasi Venkatesan |
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| Institution: | 1. PG & Research, Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India;2. Department of Humanities and Sciences, CVR College of Engineering, Vastunagar, Telangana, India |
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| Abstract: | In the present study, a series of thiodihydropyrimidine derivatives were synthesized from different substituted aromatic aldehydes, ethyl acetoacetate, and urea/thiourea using a bimetallic TUD-1 catalyst. The structures of all the synthesized compounds were characterized by melting point determination, thin layer chromatography (TLC), infrared (IR), 1HNMR, and 13C-NMR values. All the synthesized compounds were screened for their antimicrobial activities against two gram positive bacteria, two-gram negative bacteria, and two fungal strains. |
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| Keywords: | antibacterial antifungal thiodihydropyrimidine |
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