| Abstract: | In continuing search for novel cell differentiation agents, a series of derivatives of indole‐3‐acetic acid and indole‐3‐carboxylic acid were prepared and tested against HL‐60 cells for their differentiation and antiproliferation activities. Among them, N‐ethyl‐1‐benzylindole‐3‐carboxamide ( 14 ) was the most potent, whereas N‐methyl 1‐benzylindole‐3‐acetamide ( 5 ) and N‐methyl 1‐benzylindole‐3‐carboxamide ( 13 ) synergistically potentiated with all‐trans‐retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid. |
