Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry |
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Authors: | Merchant M Weinberger S R |
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Institution: | Ciphergen Biosystems, Inc., Palo Alto, CA 94306, USA. |
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Abstract: | The overall history and recent advances in surface enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) technology is reviewed herein. Fundamentals of SELDI-TOF analysis are presented while drawing comparisons with other laser-based mass spectrometry techniques. The application of SELDI-TOF-MS to functional genomics and biomarker discovery is discussed and exemplified by elucidating a biomarker candidate for prostatic carcinoma. Finally, a short discussion regarding future SELDI requirements and developments is supplied. |
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